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Protein Coding Gene : Cldn15 claudin 15

Primary Identifier  MGI:1913103 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  60363
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable identical protein binding activity and paracellular tight junction channel activity. Involved in paracellular transport; regulation of intestinal D-glucose absorption; and regulation of intestinal lipid absorption. Located in lateral plasma membrane and tight junction. Is expressed in intestine epithelium; lung; metanephros; pancreas; and stomach. Orthologous to human CLDN15 (claudin 15).
PHENOTYPE: Mice homozygous for a knock-out allele are viable and grow normally with an enlarged upper small intestinal phenotype (megaintestine) resulting from enhanced proliferation of normal cryptic cells after weaning. [provided by MGI curators]
  • synonyms:
  • MGI:1914340,
  • 2210009B08Rik,
  • expressed sequence BB107105,
  • BB107105,
  • Cldn15,
  • RIKEN cDNA 2210009B08 gene,
  • MGI:2141263,
  • claudin 15

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Genome

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

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Disease

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