| Primary Identifier | MGI:3042776 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 414801 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein kinase inhibitor activity. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in nuclear outer membrane. Orthologous to human ITPRIP (inositol 1,4,5-trisphosphate receptor interacting protein). PHENOTYPE: Mice homozygous for a null mutation are grossly normal, but MEF and neuronal cells show increased susceptibility to induced cell death due to increase in death-associated protein kinase (DAPK) activity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
