| Primary Identifier | MGI:107546 | Organism | mouse, laboratory |
| Chromosome | 7 | Mgi Type | polymorphic pseudogene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables NAD+-protein-arginine ADP-ribosyltransferase activity and hydrolase activity, acting on glycosyl bonds. Involved in NAD catabolic process. Located in external side of plasma membrane. PHENOTYPE: A targeted mutation in this gene indirectly regulates T-cell apoptosis. [provided by MGI curators] |
| specificity | Sequence analysis of the endogenous loci of C57BL/6 and BALB/c mice revealed 9 nucleotide differences between the two backgrounds. Codon 481 on the C57BL/6 background encodes an in-frame stop signal, putatively precluding the translation of the essential glycosylphosphatidylinositol (GPI) anchor. Protein was undetected by Western blot analysis of COS1 cells transfected with the C57BL/6 variant. The absence of functional protein was confirmed by a lack of ADP-ribosyltransferase activity in the COS1 cells. |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
