| First Author | Behrens J | Year | 1998 |
| Journal | Science | Volume | 280 |
| Issue | 5363 | Pages | 596-9 |
| PubMed ID | 9554852 | Mgi Jnum | J:47363 |
| Mgi Id | MGI:1203346 | Doi | 10.1126/science.280.5363.596 |
| Citation | Behrens J, et al. (1998) Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 280(5363):596-9 |
| abstractText | Control of stability of beta-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a complex with both beta-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC). Conductin induced beta-catenin degradation, whereas mutants of conductin that were deficient in complex formation stabilized beta-catenin. Fragments of APC that contained a conductin-binding domain also blocked beta-catenin degradation. Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation. |
