| First Author | Oquendo P | Year | 1989 |
| Journal | J Biol Chem | Volume | 264 |
| Issue | 7 | Pages | 4133-7 |
| PubMed ID | 2917992 | Mgi Jnum | J:22692 |
| Mgi Id | MGI:70550 | Doi | 10.1016/s0021-9258(19)84972-4 |
| Citation | Oquendo P, et al. (1989) The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins. J Biol Chem 264(7):4133-7 |
| abstractText | A full length cDNA clone of the platelet-derived growth factor-inducible KC gene has been isolated, sequenced, and expressed in COS cells. Both sequence analysis and expression studies indicate that KC encodes a secretory protein. Sequence analysis shows that, furthermore, the protein encoded by KC belongs to a growing superfamily of inducible proteins with a common ancestral linkage to the platelet alpha-granule proteins, platelet factor 4, and connective tissue-activating peptide III. A computer-generated phylogenetic tree documents interrelationships between KC and six additional members of this peptide superfamily. The KC gene is, in all probability, the murine homologue of a human gene termed gro. By extension, the KC protein is the murine counterpart of the protein encoded by the gro gene. The gro protein corresponds to a factor described as melanoma growth-stimulating activity. |
