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Publication : Structure and polymorphism of the mouse myelin/oligodendrocyte glycoprotein gene.

First Author  Daubas P Year  1994
Journal  Genomics Volume  23
Issue  1 Pages  36-41
PubMed ID  7829100 Mgi Jnum  J:20138
Mgi Id  MGI:68252 Doi  10.1006/geno.1994.1456
Citation  Daubas P, et al. (1994) Structure and polymorphism of the mouse myelin/oligodendrocyte glycoprotein gene. Genomics 23(1):36-41
abstractText  We have isolated and characterized genomic clones containing the mouse myelin/oligodendrocyte glycoprotein (MOG) gene. It spans a region of 12.5 kb and consists of eight exons. Its exon-intron structure differs from that of classical MHC-class I genes, with which it is linked in the mouse genome. Nucleotide sequencing of the 5' flanking region reveals that it contains several putative protein-binding sites, some of them in common with other myelin gene promoters. One intragenic polymorphism has been identified: it consists of a GA repeat, defining at least three alleles in mouse inbred strains, and is easily detectable using the polymerase chain reaction method.
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