| First Author | Wilkinson MF | Year | 1990 |
| Journal | Dev Biol | Volume | 141 |
| Issue | 2 | Pages | 451-5 |
| PubMed ID | 2210045 | Mgi Jnum | J:10765 |
| Mgi Id | MGI:59211 | Doi | 10.1016/0012-1606(90)90400-d |
| Citation | Wilkinson MF, et al. (1990) A novel oncofetal gene is expressed in a stage-specific manner in murine embryonic development [published erratum appears in Dev Biol 1991 Jul;146(1):263]. Dev Biol 141(2):451-5 |
| abstractText | A novel cDNA clone obtained from a murine T-lymphoma library hybridizes to transcripts expressed in placenta and embryos (Pem) in a stage-specific manner. The Pem cDNA sequence predicts an intracellular hydrophilic protein with no significant sequence similarity to other DNA or protein sequences. Pem transcripts are abundant in 7- and 8-day mouse embryos, but decrease precipitously thereafter. On Day 9 they become abundant in placenta and yolk sac, persisting there until parturition. Although Pem transcripts are present in immortalized and tumorigenic cell lines from several different cell lineages, they are not detectable in any of 15 adult tissues tested. The expression of Pem during fetal development and its presence in immortalized and neoplastic cell lines is consistent with the properties expected of an oncofetal gene. |
