First Author | Bilinski P | Year | 1996 |
Journal | Biochem J | Volume | 320 ( Pt 2) |
Pages | 359-63 | PubMed ID | 8973540 |
Mgi Jnum | J:37144 | Mgi Id | MGI:84572 |
Doi | 10.1042/bj3200359 | Citation | Bilinski P, et al. (1996) Two differentially expressed interleukin-11 receptor genes in the mouse genome. Biochem J 320(Pt 2):359-63 |
abstractText | Interleukin-ll (IL-11) is a multifunctional cytokine involved in the regulation of cell proliferation and differentiation in a variety of cell types and tissues in vitro and in vivo. The effects of IL-11 were shown to be mediated by the IL-11 receptor (hereafter referred to as IL-11R alpha), which is a ligand-binding subunit and provides ligand specificity in a functional multimeric signal-transduction complex with gp130. Here we show that the mouse genome contains a second gene encoding an IL-11- binding protein, referred to as IL-11R beta. The structure of the IL-11R beta gene is highly similar to that of IL- 11R alpha, and IL-11R beta exhibits 99% sequence identity with IL-11R alpha at the amino acid level. IL-11R beta is co-expressed with IL-11R alpha, albeit at lower levels, in embryos and in various adult tissues. IL-11R beta transcripts are abundant in testis, and, in contrast with IL-11R alpha, absent from skeletal muscle, IL-11R beta expressed in vitro binds IL-11 with high affinity, suggesting that the mouse genome contains a second functional IL-11R. |