| First Author | Harada T | Year | 1994 |
| Journal | Biochem Biophys Res Commun | Volume | 205 |
| Issue | 2 | Pages | 1057-63 |
| PubMed ID | 7802632 | Mgi Jnum | J:22015 |
| Mgi Id | MGI:69909 | Doi | 10.1006/bbrc.1994.2773 |
| Citation | Harada T, et al. (1994) Murine fibroblast growth factor receptor 1 gene generates multiple messenger RNAs containing two open reading frames via alternative splicing. Biochem Biophys Res Commun 205(2):1057-63 |
| abstractText | The arrangement of exons and introns encoding 5'-side of murine fibroblast growth factor (FGF) receptor 1 (FGFR-1) gene was mapped. A large intron with a size of 14 kb was identified between exon 1 and exon 2. In addition, all FGFR-1 subtypes including a unique variant form with 12 amino acids insertion and two amino acids deletion were observed to be able to be generated through alternative splicing. Furthermore, complete sequencing of the 5'-region of FGFR-1 mRNA revealed that a relatively large open reading frame precedes the major open reading frame encoding FGFR-1. These results indicate that FGFR-1 mRNAs are uniquely translated from an internal translation start site. |
