| First Author | Monaco JJ | Year | 1990 |
| Journal | Science | Volume | 250 |
| Issue | 4988 | Pages | 1723-6 |
| PubMed ID | 2270487 | Mgi Jnum | J:10934 |
| Mgi Id | MGI:59377 | Doi | 10.1126/science.2270487 |
| Citation | Monaco JJ, et al. (1990) Transport protein genes in the murine MHC: possible implications for antigen processing. Science 250(4988):1723-6 |
| abstractText | T lymphocyte activation requires recognition by the T cell of peptide fragments of foreign antigen bound to a self major histocompatibility complex (MHC) molecule. Genetic evidence suggests that part of the class II region of the MHC influences the expression, in trans, of MHC class I antigens on the cell surface, by regulating the availability of peptides that bind to and stabilize the class I molecule. Two closely related genes in this region, HAM1 and HAM2, were cloned and had sequence similarities to a superfamily of genes involved in the ATP-dependent transport of a variety of substrates across cell membranes. Thus, these MHC-linked transport protein genes may be involved in transporting antigen, or peptide fragments thereof, from the cytoplasm into a membrane-bounded compartment containing newly synthesized MHC molecules. |
