| First Author | Wang H | Year | 2011 |
| Journal | Front Biosci (Elite Ed) | Volume | 3 |
| Pages | 1241-8 | PubMed ID | 21622130 |
| Mgi Jnum | J:192794 | Mgi Id | MGI:5466484 |
| Doi | 10.2741/E327 | Citation | Wang H, et al. (2011) Involvement of LOC66273 isoform 2, a novel Mth938 containing protein, in MAPK pathway. Front Biosci (Elite Ed) 3:1241-8 |
| abstractText | Using dual-luciferase reporter assay system, our previous study showed that LI2, significantly increased AP-1 transcriptional activity. Sub-cellular localization showed that GFP-LI2 fusion protein is diffusely distributed in the cytoplasm, with some highly concentrated spots around the nucleus, suggesting that LI2 protein has a physiological role in cytoplasm. Overexpression of LI2 significantly increased AP-1 transcriptional activity. Moreover, LI2 significantly promoted transcriptional activity of Elk1 and c-jun, which might, at least partly, be associated with activated ERK1/2 and JNK/SAPK signaling pathway. These data suggest that LI2 is a novel MAPK regulating protein. |
