| First Author | Ohmori Y | Year | 1990 |
| Journal | Biochem Biophys Res Commun | Volume | 168 |
| Issue | 3 | Pages | 1261-7 |
| PubMed ID | 2189406 | Mgi Jnum | J:10527 |
| Mgi Id | MGI:58977 | Doi | 10.1016/0006-291x(90)91164-n |
| Citation | Ohmori Y, et al. (1990) A macrophage LPS-inducible early gene encodes the murine homologue of IP-10. Biochem Biophys Res Commun 168(3):1261-7 |
| abstractText | Recently, we have isolated and characterized a set of cDNA clones which encode lipopolysaccharide-inducible proteins in murine peritoneal macrophages. Here, we report the sequence and identification of one of these cDNAs previously termed C7. Nucleotide sequence analysis revealed an open reading frame encoding a predicted polypeptide composed of 98 amino acids, which contained a 21 amino acid residue signal peptide, indicating approximately 9 kDa of mature protein. The deduced protein sequence showed homology (67% identity, 77% considering conservative amino acid changes) with the human INF gamma-inducible gene IP-10, a member of the recently described superfamily of chemotactic and mitogenic proteins which includes platelet factor 4, monocyte-derived neutrophil chemotactic factor (NAF, NAP-1, IL-8), and MGSA/gro/KC. Thus C7 would appear to represent the murine homologue of the human IP-10 gene or a very closely related gene. |
