| First Author | Weisstaub NV | Year | 2006 |
| Journal | Science | Volume | 313 |
| Issue | 5786 | Pages | 536-40 |
| PubMed ID | 16873667 | Mgi Jnum | J:110958 |
| Mgi Id | MGI:3652451 | Doi | 10.1126/science.1123432 |
| Citation | Weisstaub NV, et al. (2006) Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science 313(5786):536-40 |
| abstractText | Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system modulates depression and anxiety-related behaviors in humans and rodents, but the responsible downstream receptors remain poorly understood. We demonstrate that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors. Selective restoration of 5HT2AR signaling to the cortex normalized conflict anxiety behaviors. These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, 'top-down' influences on risk assessment. |
