| First Author | Cisek LJ | Year | 1989 |
| Journal | Nature | Volume | 339 |
| Issue | 6227 | Pages | 679-84 |
| PubMed ID | 2662013 | Mgi Jnum | J:9854 |
| Mgi Id | MGI:58311 | Doi | 10.1038/339679a0 |
| Citation | Cisek LJ, et al. (1989) Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2. Nature 339(6227):679-84 |
| abstractText | Actively transcribing eukaryotic RNA polymerase II is highly phosphorylated on its repetitive carboxyl-terminal domain. We have isolated a protein kinase that phosphorylates serine residues in this repetitive domain. A component of this kinase is cdc2, the product of a cell-cycle control gene previously shown to be a component of M-phase-promoting factor and M-phase-specific histone H1 kinase. This observation suggests a role for the cdc2 protein kinase in transcriptional regulation. |
