| First Author | Matsushime H | Year | 1991 |
| Journal | Cell | Volume | 65 |
| Issue | 4 | Pages | 701-13 |
| PubMed ID | 1827757 | Mgi Jnum | J:14776 |
| Mgi Id | MGI:62938 | Doi | 10.1016/0092-8674(91)90101-4 |
| Citation | Matsushime H, et al. (1991) Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65(4):701-13 |
| abstractText | Three mouse cyclin-like (CYL) genes were isolated, two of which are regulated by colony-stimulating factor 1 (CSF-1) during the G1 phase of the macrophage cell cycle. CSF-1 deprivation during G1 leads to rapid degradation of CYL proteins (p36CYL) and correlates with failure to initiate DNA synthesis. However, after entering S phase, macrophages no longer require CSF-1 and can complete cell division without expressing CYL genes. During G1, p36CYL is phosphorylated and associates with a polypeptide antigenically related to p34cdc2. The timing of p36CYL expression, its rapid turnover in the absence of CSF-1, and its phosphorylation and transient binding to a cdc2-related polypeptide suggest that CYL genes may function during S phase commitment. |
