| First Author | Yang XF | Year | 1997 |
| Journal | Immunity | Volume | 7 |
| Issue | 5 | Pages | 629-39 |
| PubMed ID | 9390687 | Mgi Jnum | J:44363 |
| Mgi Id | MGI:1099944 | Doi | 10.1016/s1074-7613(00)80384-2 |
| Citation | Yang XF, et al. (1997) A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells. Immunity 7(5):629-39 |
| abstractText | We define a novel Bcl-x isoform, Bcl-x gamma, that is generated by alternative splicing and characterized by a unique 47 amino acid C-terminus. Bcl-x gamma is expressed primarily in thymocytes, where it may depend on an interaction between the TCR and host MHC products, and in mature T cells, where its expression is associated with ligation of the T cell receptor. Overexpression of Bcl-x gamma in T cells inhibits activation-induced apoptosis; inhibition of Bcl-x gamma, after stable expression of Bcl-x gamma antisense cDNA, enhances activation-induced apoptosis. In contrast to other Bcl-x isoforms, cells that fail to express Bcl-x gamma after CD3 ligation undergo programmed cell death, while activated T cells that express Bcl-x gamma are spared. Identification of Bcl-x gamma helps provide a molecular explanation of T cell activation and death after antigen engagement. |
