| First Author | Weber HC | Year | 1998 |
| Journal | Gene | Volume | 211 |
| Issue | 1 | Pages | 125-31 |
| PubMed ID | 9573346 | Mgi Jnum | J:47585 |
| Mgi Id | MGI:1203808 | Doi | 10.1016/s0378-1119(98)00050-x |
| Citation | Weber HC, et al. (1998) Structure and chromosomal localization of the mouse bombesin receptor subtype 3 gene. Gene 211(1):125-31 |
| abstractText | Bombesin (BN)-like peptides/neurotransmitters mediate a broad range of physiological funtions in the gastrointestinal tract and the central nervous system through binding to their specific, high-affinity mammalian bombesin receptors. This family of heptahelical, G protein- coupled receptors includes the gastrin-releasing peptide receptor (GRP-R, or bb2), neuromedin B receptor (NMB-R, or bbl), and the bombesin receptor subtype 3 (BRS-3, or bb3). The tissue distribution of BRS-3 is quite dissimilar compared to the other two BN receptors, GRP-R and NMB-R, and a natural ligand for BRS-3 is currently unknown. Nothing is known about mechanisms regulating BRS-3 gene expression and possible association with disease. To gain insight into the underlying structure and chromosomal localization of the BRS-3 genes, bacteriophage P1 genomic clones, harboring the genes for the human and mouse BRS-3, respectively, were isolated and their structure and chromosomal localizations determined. The protein-coding region of both genes is divided into three exons and spans approximately 5 kb. The loci of the BRS-3 genes were mapped to a syntenic region of the human (Xq25) and mouse (XA7.1-7.2) X-chromosome, respectively. The structural data of the BRS-3 genes derived from this study will permit future investigations of the mechanisms regulating their expression. (C) 1998 Elsevier Science B.V. All rights reserved. |
