| First Author | Berg AH | Year | 2001 |
| Journal | Nat Med | Volume | 7 |
| Issue | 8 | Pages | 947-53 |
| PubMed ID | 11479628 | Mgi Jnum | J:93108 |
| Mgi Id | MGI:3055866 | Doi | 10.1038/90992 |
| Citation | Berg AH, et al. (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7(8):947-53 |
| abstractText | Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism. |
