| First Author | Orr-Urtreger A | Year | 1995 |
| Journal | Genomics | Volume | 26 |
| Issue | 2 | Pages | 399-402 |
| PubMed ID | 7601470 | Mgi Jnum | J:24219 |
| Mgi Id | MGI:71968 | Doi | 10.1016/0888-7543(95)80228-e |
| Citation | Orr-Urtreger A, et al. (1995) Cloning and mapping of the mouse alpha 7-neuronal nicotinic acetylcholine receptor. Genomics 26(2):399-402 |
| abstractText | We report the isolation of cDNA clones for the mouse alpha 7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind alpha-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse alpha 7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6%), human (92.8%), and chicken (87.5%) amino acid sequences. The alpha 7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 +/- 1.7 cM-Gas2-0.9 cM +/- 0.9 cM-D7Mit70-1.8 +/- 1.2 cM-Acra7-4.4 +/- 1.0 cM-Hras1-ps1/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14. |
