| First Author | Lee JH | Year | 1999 |
| Journal | Oncogene | Volume | 18 |
| Issue | 46 | Pages | 6183-90 |
| PubMed ID | 10597216 | Mgi Jnum | J:58551 |
| Mgi Id | MGI:1349210 | Doi | 10.1038/sj.onc.1203043 |
| Citation | Lee JH, et al. (1999) Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene 18(46):6183-90 |
| abstractText | Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood. Using a protein interaction cloning procedure, we identified a human gene designated as bis (mapped to chromosome 10q25) that encoded a novel Bcl-2-interacting protein. Bis protein showed no significant homology with Bcl-2 family proteins and had no prominent functional motif. Co-immunoprecipitation analysis confirmed that Bis interacted with Bcl-2 in vivo. DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis. These results suggest that Bis is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with Bcl-2. |
