| First Author | Thompson DA | Year | 1998 |
| Journal | Biochem Biophys Res Commun | Volume | 251 |
| Issue | 1 | Pages | 111-6 |
| PubMed ID | 9790916 | Mgi Jnum | J:54318 |
| Mgi Id | MGI:1334928 | Doi | 10.1006/bbrc.1998.9440 |
| Citation | Thompson DA, et al. (1998) hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines. Biochem Biophys Res Commun 251(1):111-6 |
| abstractText | hAG-2, the human homologue of the Xenopus laevis cement gland gene Xenopus Anterior Gradient-2 (XAG-2), has been found to be coexpressed with estrogen receptor (ER) in breast cancer cell lines by using suppression subtractive hybridization. Sequence analysis of clones obtained from a human breast adenocarcinoma MCF7 cDNA library suggests that at least three mRNA transcripts, differing in their 3'- untranslated regions, are transcribed from the hAG-2 gene. Northern blot analyses identified two principal hAG-2 signals in all ER-positive breast carcinoma cell lines that were absent in cell lines not expressing, or minimally expressing, ER. Coexpression of hAG-2 with ER suggests that hAG-2 may be involved in the tumor biology specific to the well-differentiated phenotype of hormonally-responsive breast cancers. Copyright 1998 Academic Press. |
