| First Author | Huleihel M | Year | 1986 |
| Journal | Mol Cell Biol | Volume | 6 |
| Issue | 7 | Pages | 2655-62 |
| PubMed ID | 3491291 | Mgi Jnum | J:8502 |
| Mgi Id | MGI:56968 | Doi | 10.1128/mcb.6.7.2655 |
| Citation | Huleihel M, et al. (1986) Characterization of murine A-raf, a new oncogene related to the v-raf oncogene. Mol Cell Biol 6(7):2655-62 |
| abstractText | A 1.6-kilobase cDNA (A-raf) has been isolated from a murine spleen cDNA library which encodes part of a protein related to the raf oncogene. Its amino acid sequence has 85% homology to raf in a central portion of 100 amino acids. In contrast to raf, A-raf shows a highly restricted tissue distribution of expression, with highest levels observed in epididymis, followed by intestine. When incorporated into a retrovirus, the resulting gag-A-raf fusion gene causes transformation in vitro and induces tumors in newborn mice. Thus, A-raf represents a new proto-oncogene. Transformation by A-raf is independent of ras gene function, as is the case for raf and mos but not other oncogenes. |
