| First Author | Hannon R | Year | 2003 |
| Journal | FASEB J | Volume | 17 |
| Issue | 2 | Pages | 253-5 |
| PubMed ID | 12475898 | Mgi Jnum | J:81498 |
| Mgi Id | MGI:2449418 | Doi | 10.1096/fj.02-0239fje |
| Citation | Hannon R, et al. (2003) Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB J 17(2):253-5 |
| abstractText | The 37-kDa protein annexin 1 (Anx-1; lipocortin 1) has been implicated in the regulation of phagocytosis, cell signaling, and proliferation and is postulated to be a mediator of glucocorticoid action in inflammation and in the control of anterior pituitary hormone release. Here, we report that mice lacking the Anx-1 gene exhibit a complex phenotype that includes an altered expression of other annexins as well as of COX-2 and cPLA2. In carrageenin- or zymosan-induced inflammation, Anx-1-/- mice exhibit an exaggerated response to the stimuli characterized by an increase in leukocyte emigration and IL-1beta generation and a partial or complete resistance to the antiinflammatory effects of glucocorticoids. Anx-1-/- polymorphonuclear leucocytes exhibited increased spontaneous migratory behavior in vivo whereas in vitro, leukocytes from Anx-1-/- mice had reduced cell surface CD 11b (MAC-1) but enhanced CD62L (L-selectin) expression and Anx-1-/- macrophages exhibited anomalies in phagocytosis. There are also gender differences in activated leukocyte behavior in the Anx-1-/- mice that are not seen in the wild-type animals, suggesting an interaction between sex hormones and inflammation in Anx-1-/- animals. |
