| First Author | Feyerabend TB | Year | 2006 |
| Journal | Nat Chem Biol | Volume | 2 |
| Issue | 4 | Pages | 195-6 |
| PubMed ID | 16532012 | Mgi Jnum | J:349025 |
| Mgi Id | MGI:7646077 | Doi | 10.1038/nchembio777 |
| Citation | Feyerabend TB, et al. (2006) Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells. Nat Chem Biol 2(4):195-6 |
| abstractText | Biosynthesis of heparin, a mast cell-derived glycosaminoglycan with widespread importance in medicine, has not been fully elucidated. In biosynthesis of heparan sulfate (HS), a structurally related polysaccharide, HS glucuronyl C5-epimerase (Hsepi) converts D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) residues. We have generated Hsepi-null mouse mutant mast cells, and we show that the same enzyme catalyzes the generation of IdoA in heparin and that 'heparin' lacking IdoA shows a distorted O-sulfation pattern. |
