| First Author | Plath N | Year | 2006 |
| Journal | Neuron | Volume | 52 |
| Issue | 3 | Pages | 437-44 |
| PubMed ID | 17088210 | Mgi Jnum | J:122980 |
| Mgi Id | MGI:3716049 | Doi | 10.1016/j.neuron.2006.08.024 |
| Citation | Plath N, et al. (2006) Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron 52(3):437-44 |
| abstractText | Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage. |
