| First Author | Butz S | Year | 1994 |
| Journal | FEBS Lett | Volume | 355 |
| Issue | 2 | Pages | 195-200 |
| PubMed ID | 7982500 | Mgi Jnum | J:37378 |
| Mgi Id | MGI:84774 | Doi | 10.1016/0014-5793(94)01205-9 |
| Citation | Butz S, et al. (1994) Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion. FEBS Lett 355(2):195-200 |
| abstractText | Catenins are peripheral cytoplasmic proteins originally identified in association with the mouse epithelial cell adhesion molecule E-cadherin. Molecular cloning and primary structure analysis demonstrated that alpha-catenin is homologous to vinculin and the beta-catenin is homologous to human plakoglobin and the Drosophila gene product armadillo. With the use of peptide-specific anti plakoglobin antibodies were confirm here that plakoglobin is a component of the cadherin-catenin complex and that it is most likely identical to gamma-catenin. We show that plakoglobin binds directly to E-cadherin. We consolidate the biochemical evidence for the existence of two distinct and separable E-cadherin-catenin complexes in the same cell. One complex is composed of E-cadherin, alpha- and beta-catenin, the other of E-cadherin, alpha-catenin and plakoglobin. A similar distinct association with catenins is also found for other cadherins. Comparison of different cell lines revealed that the relative amounts of the two complexes vary depending on cell types. |
