| First Author | Cheng HY | Year | 2002 |
| Journal | Cell | Volume | 108 |
| Issue | 1 | Pages | 31-43 |
| PubMed ID | 11792319 | Mgi Jnum | J:74345 |
| Mgi Id | MGI:2158115 | Doi | 10.1016/s0092-8674(01)00629-8 |
| Citation | Cheng HY, et al. (2002) DREAM is a critical transcriptional repressor for pain modulation. Cell 108(1):31-43 |
| abstractText | Control and treatment of chronic pain remain major clinical challenges. Progress may be facilitated by a greater understanding of the mechanisms underlying pain processing. Here we show that the calcium-sensing protein DREAM is a transcriptional repressor involved in modulating pain. dream(-/-) mice displayed markedly reduced responses in models of acute thermal, mechanical, and visceral pain. dream(-/-) mice also exhibited reduced pain behaviors in models of chronic neuropathic and inflammatory pain. However, dream(-/-) mice showed no major defects in motor function or learning and memory. Mice lacking DREAM had elevated levels of prodynorphin mRNA and dynorphin A peptides in the spinal cord, and the reduction of pain behaviors in dream(-/-) mice was mediated through dynorphin-selective kappa (kappa)-opiate receptors. Thus, DREAM appears to be a critical transcriptional repressor in pain processing. |
