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Publication : cDNA cloning, sequence analysis and tissue distribution of a precursor for vasoactive intestinal contractor (VIC).

First Author  Saida K Year  1991
Journal  Biochim Biophys Acta Volume  1089
Issue  3 Pages  404-6
PubMed ID  1859843 Mgi Jnum  J:11349
Mgi Id  MGI:59785 Doi  10.1016/0167-4781(91)90186-p
Citation  Saida K, et al. (1991) cDNA cloning, sequence analysis and tissue distribution of a precursor for vasoactive intestinal contractor (VIC). Biochim Biophys Acta 1089(3):404-6
abstractText  A full-length cDNA encoding preprovasoactive intestinal contractor (PPVIC) has been cloned. From the deduced 160 amino acid PPVIC, the mature VIC is predicted to be produced via a 37 residue intermediate, big VIC. The PPVIC also contains a VIC-like peptide of 16 amino acids structurally related to to the amino-terminal residues of VIC and flanked by pairs of dibasic amino acids, putative processing sites. RNA blot hybridization with PPVIC cDNA confirmed the PPVIC gene to be expressed in the small and large intestinal tract in a tissue specific manner.
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