| First Author | Zhu X | Year | 2002 |
| Journal | FEBS Lett | Volume | 524 |
| Issue | 1-3 | Pages | 116-22 |
| PubMed ID | 12135752 | Mgi Jnum | J:77794 |
| Mgi Id | MGI:2182643 | Doi | 10.1016/s0014-5793(02)03014-4 |
| Citation | Zhu X, et al. (2002) Mouse cone arrestin gene characterization: promoter targets expression to cone photoreceptors. FEBS Lett 524(1-3):116-22 |
| abstractText | Cone arrestin (CAR) is a novel member of the arrestin superfamily expressed in retinal cone photoreceptors and the pineal gland. To understand the regulatory mechanisms controlling its cone- and pineal-specific expression, and to facilitate further functional studies using gene knockout approaches, we characterized the genomic organization and the 5'-flanking region of the mouse CAR (mCAR) gene. The mCAR gene is comprised of 17 exons and 16 introns, encoding five alternatively spliced transcripts. A 215-bp proximal promoter fragment containing a TATA box, an Sp1 site and four cone-rod homeobox-binding sites is sufficient to direct expression in cultured retinoblastoma cells and in cone photoreceptors and the pineal gland in transgenic Xenopus laevis. |
