| First Author | Empson RM | Year | 2007 |
| Journal | J Neurosci | Volume | 27 |
| Issue | 14 | Pages | 3753-8 |
| PubMed ID | 17409239 | Mgi Jnum | J:121220 |
| Mgi Id | MGI:3709537 | Doi | 10.1523/JNEUROSCI.0069-07.2007 |
| Citation | Empson RM, et al. (2007) Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse. J Neurosci 27(14):3753-8 |
| abstractText | Plasma membrane Ca2+ ATPase 2 (PMCA2) is a fast, highly effective mechanism to control resting cytosolic Ca2+ and Ca2+ excursions in neurons and other excitable cells. The strong expression of PMCA2 in the cerebellum and the cerebellar behavioral deficits presented by PMCA2-/- knock-out mice all point to its importance for cerebellar circuit dynamics. Here, we provide direct functional evidence for the influence of presynaptic PMCA2-mediated Ca2+ extrusion for short-term plasticity at cerebellar parallel fiber to Purkinje neuron synapses. Dramatic structural alterations to the Purkinje neurons in the absence of PMCA2 also suggest a strong influence of this fast PMCA2 isoform for development and maintenance of cerebellar function. |
