| First Author | Adams NC | Year | 2002 |
| Journal | Development | Volume | 129 |
| Issue | 4 | Pages | 965-72 |
| PubMed ID | 11861479 | Mgi Jnum | J:74969 |
| Mgi Id | MGI:2159504 | Doi | 10.1242/dev.129.4.965 |
| Citation | Adams NC, et al. (2002) Mice that lack astrotactin have slowed neuronal migration. Development 129(4):965-72 |
| abstractText | The cortical regions of the brain are laminated as a result of directed migration of precursor cells along glia during development. Previously, we have used an assay system to identify astrotactin as a neuronal ligand for migration on glial fibers. To examine the function of astrotactin in vivo, we generated a null mutation by targeted gene disruption. The cerebella of astrotactin null mice are approximately 10% smaller than wild type. In vitro and in vivo cerebellar granule cell assays show a decrease in neuron-glial binding, a reduction in migration rates and abnormal development of Purkinje cells. Consequences of this are poorer balance and coordination. Thus, astrotactin functions in migration along glial processes in vivo, a process required for generating laminar structures and for the development of synaptic partner systems. |
