| First Author | Wong ST | Year | 1999 |
| Journal | Neuron | Volume | 23 |
| Issue | 4 | Pages | 787-98 |
| PubMed ID | 10482244 | Mgi Jnum | J:57343 |
| Mgi Id | MGI:1344240 | Doi | 10.1016/s0896-6273(01)80036-2 |
| Citation | Wong ST, et al. (1999) Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP. Neuron 23(4):787-98 |
| abstractText | It is hypothesized that Ca2+ stimulation of calmodulin (CaM)-activated adenylyl cyclases (AC1 or AC8) generates cAMP signals critical for late phase LTP (L-LTP) and long-term memory (LTM). However, mice lacking either AC1 or AC8 exhibit normal L-LTP and LTM. Here, we report that mice lacking both enzymes (DKO) do not exhibit L-LTP or LTM. To determine if these defects are due to a loss of cAMP increases in the hippocampus, DKO mice were unilaterally cannulated to deliver forskolin. Administration of forskolin to area CA1 before training restored normal LTM. We conclude that Ca2+-stimulated adenylyl cyclase activity is essential for L-LTP and LTM and that AC1 or AC8 can produce the necessary cAMP signal. |
