| First Author | Koishi R | Year | 2002 |
| Journal | Nat Genet | Volume | 30 |
| Issue | 2 | Pages | 151-7 |
| PubMed ID | 11788823 | Mgi Jnum | J:75358 |
| Mgi Id | MGI:2176373 | Doi | 10.1038/ng814 |
| Citation | Koishi R, et al. (2002) Angptl3 regulates lipid metabolism in mice. Nat Genet 30(2):151-7 |
| abstractText | The KK obese mouse is moderately obese and has abnormally high levels of plasma insulin (hyperinsulinemia), glucose (hyperglycemia) and lipids (hyperlipidemia). In one strain (KK/San), we observed abnormally low plasma lipid levels (hypolipidemia). This mutant phenotype is inherited recessively as a mendelian trait. Here we report the mapping of the hypolipidemia (hypl) locus to the middle of chromosome 4 and positional cloning of the autosomal recessive mutation responsible for the hypolipidemia. The hypl locus encodes a unique angiopoietin-like lipoprotein modulator, which we named Allm1. It is identical to angiopoietin-like protein 3, encoded by Angptl3, and has a highly conserved counterpart in humans. Overexpression of Angptl3 or intravenous injection of the purified protein in KK/San mice elicited an increase in circulating plasma lipid levels. This increase was also observed in C57BL/6J normal mice. Taken together, these data suggest that Angptl3 regulates lipid metabolism in animals. |
