| First Author | Kamura T | Year | 1999 |
| Journal | Science | Volume | 284 |
| Issue | 5414 | Pages | 657-61 |
| PubMed ID | 10213691 | Mgi Jnum | J:64811 |
| Mgi Id | MGI:1890005 | Doi | 10.1126/science.284.5414.657 |
| Citation | Kamura T, et al. (1999) Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase [see comments]. Science 284(5414):657-61 |
| abstractText | The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in most human kidney cancers. The VHL protein is part of a complex that includes Elongin B, Elongin C, and Cullin-2, proteins associated with transcriptional elongation and ubiquitination. Here it is shown that the endogenous VHL complex in rat liver also includes Rbx1, an evolutionarily conserved protein that contains a RING-H2 fingerlike motif and that interacts with Cullins. The yeast homolog of Rbx1 is a subunit and potent activator of the Cdc53-containing SCFCdc4 ubiquitin ligase required for ubiquitination of the cyclin-dependent kinase inhibitor Sic1 and for the G1 to S cell cycle transition. These findings provide a further link between VHL and the cellular ubiquitination machinery. |
