| First Author | Lai F | Year | 1994 |
| Journal | Genomics | Volume | 22 |
| Issue | 3 | Pages | 610-6 |
| PubMed ID | 8001972 | Mgi Jnum | J:19871 |
| Mgi Id | MGI:67994 | Doi | 10.1006/geno.1994.1434 |
| Citation | Lai F, et al. (1994) Molecular analysis of mouse Rab11b: a new type of mammalian YPT/Rab protein. Genomics 22(3):610-6 |
| abstractText | Since the realization that the vesicular transport machinery is conserved from yeast to vertebrate neurons, much interest in the proteins involved has been generated. Here we describe a new type of mammalian YPT/Rab protein, named Rab11b, that is most abundantly expressed in brain, heart, and testis. It has all the hallmarks of a YPT3/Rab11 protein, but is more closely related to a ypt3-related gene isolated from fish (97% homology) than to the previously described four mammalian Rab11 genes (89% homology). The mammalian Rab11 genes discovered previously are, by contrast, 100% identical to each other. The genomic structure of a mammalian Rab11 protein is described for the first time. It is surprisingly asymmetrical, with 96% of the coding sequence contained in one-third of the transcription unit. Two copies of this gene are mapped to mouse chromosomes 1 and 17. The fine structural analysis of Rab11b and the protein sequence comparison provides a close look at all YPT3/Rab11-related genes cloned so far and clues to their possible relationship. |
