| First Author | Takemoto T | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 2 | Pages | 218-22 |
| PubMed ID | 17188681 | Mgi Jnum | J:118259 |
| Mgi Id | MGI:3699031 | Doi | 10.1016/j.febslet.2006.12.014 |
| Citation | Takemoto T, et al. (2007) RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet. FEBS Lett 581(2):218-22 |
| abstractText | In rodents a high-fructose diet induces metabolic derangements similar to those in metabolic syndrome. Previously we suggested that in mouse liver an unidentified nuclear protein binding to the sterol regulatory element (SRE)-binding protein-1c (SREBP-1c) promoter region plays a key role for the response to high-fructose diet. Here, using MALDI-TOF MASS technique, we identified an X-chromosome-linked RNA binding motif protein (RBMX) as a new candidate molecule. In electrophoretic mobility shift assay, anti-RBMX antibody displaced the bands induced by fructose-feeding. Overexpression or suppression of RBMX on rat hepatoma cells regulated the SREBP-1c promoter activity. RBMX may control SREBP-1c expression in mouse liver in response to high-fructose diet. |
