| First Author | Hörlein AJ | Year | 1995 |
| Journal | Nature | Volume | 377 |
| Issue | 6548 | Pages | 397-404 |
| PubMed ID | 7566114 | Mgi Jnum | J:29044 |
| Mgi Id | MGI:76569 | Doi | 10.1038/377397a0 |
| Citation | Horlein AJ, et al. (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor [see comments]. Nature 377(6548):397-404 |
| abstractText | Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila. |
