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Publication : Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus.

First Author  Van Beveren C Year  1981
Journal  Nature Volume  289
Issue  5795 Pages  258-62
PubMed ID  6256659 Mgi Jnum  J:32392
Mgi Id  MGI:79889 Doi  10.1038/289258a0
Citation  Van Beveren C, et al. (1981) Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus. Nature 289(5795):258-62
abstractText  The complete nucleotide sequence of the transforming gene of a mouse sarcoma virus has been determined. It codes for a protein of 374 amino acids. The nucleotide sequence of the junctions between a murine leukaemia virus and cellular sequences leading to the formation of the viral transforming gene have also been elucidated. The viral transforming sequence and its cellular homologue share an uninterrupted stretch of 1,159 nucleotides, with few base substitutions. The predicted amino acid sequence of the mouse sarcoma virus transforming gene was found to share considerable homology with the proposed amino acid sequence of the avian sarcoma virus oncogene (src) product.
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