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Publication : Pax7 is required for the specification of myogenic satellite cells.

First Author  Seale P Year  2000
Journal  Cell Volume  102
Issue  6 Pages  777-86
PubMed ID  11030621 Mgi Jnum  J:64793
Mgi Id  MGI:1889987 Doi  10.1016/s0092-8674(00)00066-0
Citation  Seale P, et al. (2000) Pax7 is required for the specification of myogenic satellite cells. Cell 102(6):777-86
abstractText  The paired box transcription factor Pax7 was isolated by representational difference analysis as a gene specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization revealed that Pax7 was also expressed in satellite cells residing in adult muscle. Cell culture and electron microscopic analysis revealed a complete absence of satellite cells in Pax7(-/-) skeletal muscle. Surprisingly, fluorescence-activated cell sorting analysis indicated that the proportion of muscle-derived stem cells was unaffected. Importantly, stem cells from Pax7(-/-) muscle displayed almost a 10-fold increase in their ability to form hematopoietic colonies. These results demonstrate that satellite cells and muscle-derived stem cells represent distinct cell populations. Together these studies suggest that induction of Pax7 in muscle-derived stem cells induces satellite cell specification by restricting alternate developmental programs.
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