| First Author | Karges W | Year | 1997 |
| Journal | Biochim Biophys Acta | Volume | 1360 |
| Issue | 2 | Pages | 97-101 |
| PubMed ID | 9128175 | Mgi Jnum | J:39784 |
| Mgi Id | MGI:87133 | Doi | 10.1016/s0925-4439(97)00002-1 |
| Citation | Karges W, et al. (1997) Molecular cloning of murine ICA69: diabetes-prone mice recognize the human autoimmune-epitope, Tep69, conserved in splice variants from both species. Biochim Biophys Acta 1360(2):97-101 |
| abstractText | The islet cell antigen ICA69 is an autoimmune target in most patients with insulin-dependent diabetes. Understanding its role in diabetic autoimmunity would be facilitated by an animal model. We therefore cloned mouse ICA69. The different splice variants now identified conserve Tep69, the single T cell epitope recognized by patient T cells. We show that diabetes-prone NOD mice had Tep69-specific, autoreactive T cell repertoires and thus provide a relevant model for the study of ICA69's role in diabetic autoimmunity. |
