| First Author | Moore KW | Year | 1990 |
| Journal | Science | Volume | 248 |
| Issue | 4960 | Pages | 1230-4 |
| PubMed ID | 2161559 | Mgi Jnum | J:10544 |
| Mgi Id | MGI:58994 | Doi | 10.1126/science.2161559 |
| Citation | Moore KW, et al. (1990) Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI [published erratum appears in Science 1990 Oct 26;250(4980):494]. Science 248(4960):1230-4 |
| abstractText | Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host. |
