| First Author | Wu J | Year | 1994 |
| Journal | Nat Genet | Volume | 7 |
| Issue | 4 | Pages | 491-6 |
| PubMed ID | 7951318 | Mgi Jnum | J:19543 |
| Mgi Id | MGI:67714 | Doi | 10.1038/ng0894-491 |
| Citation | Wu J, et al. (1994) The murine Xe169 gene escapes X-inactivation like its human homologue. Nat Genet 7(4):491-6 |
| abstractText | Among a number of genes that escape X-chromosome inactivation in humans, three have been evaluated in mice and unexpectedly all three are subject to X-inactivation. We report here the cloning and expression studies of a novel mouse gene, Xe169, and show that it escapes X-inactivation like its human homologue. Xe169 was assigned to band F2/F3 on the mouse X chromosome by fluorescent in situ hybridization and Southern analysis indicates that the gene is located outside the pseudoautosomal region. Homologous, but divergent, sequences exist on the Y chromosome. In vitro and in vivo studies show that Xe169 is expressed from both the active and the inactive X chromosomes. Xe169 is the first cloned non-pseudoautosomal gene that escapes X-inactivation in mice. |
