| First Author | Hinuma S | Year | 2000 |
| Journal | Nat Cell Biol | Volume | 2 |
| Issue | 10 | Pages | 703-8 |
| PubMed ID | 11025660 | Mgi Jnum | J:65018 |
| Mgi Id | MGI:1891582 | Doi | 10.1038/35036326 |
| Citation | Hinuma S, et al. (2000) New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol 2(10):703-8 |
| abstractText | Only a few RFamide peptides have been identified in mammals, although they have been abundantly found in invertebrates. Here we report the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1-3. Cells transfected with a seven-transmembrane-domain receptor, OT7T022, specifically respond to synthetic hRFRP-1 and hRFRP-3 but not to hRFRP-2. RFRP and OT7T022 mRNAs are expressed in particular regions of the rat hypothalamus, and intracerebroventricular administration of hRFRP-1 increases prolactin secretion in rats. Our results indicate that a variety of RFamide-related peptides may exist and function in mammals. |
