| First Author | Hyldig-Nielsen JJ | Year | 1983 |
| Journal | Nucleic Acids Res | Volume | 11 |
| Issue | 15 | Pages | 5055-71 |
| PubMed ID | 6308570 | Mgi Jnum | J:29719 |
| Mgi Id | MGI:77244 | Doi | 10.1093/nar/11.15.5055 |
| Citation | Hyldig-Nielsen JJ, et al. (1983) The complete nucleotide sequence of the I-E alpha d immune response gene. Nucleic Acids Res 11(15):5055-71 |
| abstractText | We have isolated and sequenced the complete murine I-E alpha immune response gene of the H-2db haplotype. The I-E alpha d gene consists of 5300 basepairs and is organized into five or possibly six exons that correspond to different domains of the alpha chain. The amino acid sequence deduced from the I-E alpha gene shows 75% homology to its human counterpart, the HLA-DR alpha chain. The absence of I-E antigen in H-2 mice is due to lack of E alpha chain synthesis. We show here that this defect is caused by a deletion in the 5' end of the I-E alpha b gene. |
