| First Author | Kanamoto T | Year | 2006 |
| Journal | Dev Dyn | Volume | 235 |
| Issue | 4 | Pages | 1142-9 |
| PubMed ID | 16477647 | Mgi Jnum | J:107204 |
| Mgi Id | MGI:3620410 | Doi | 10.1002/dvdy.20712 |
| Citation | Kanamoto T, et al. (2006) Cloning and regulation of the vertebrate homologue of lin-41 that functions as a heterochronic gene in Caenorhabditis elegans. Dev Dyn 235(4):1142-9 |
| abstractText | The Caenorhabditis elegans gene lin-41 is the one of the heterochronic genes that regulate the timing of many developmental events. MicroRNA let-7 negatively regulates the expression of lin-41 through RNA-RNA interaction on its 3' untranslated region (UTR). Here, we report the isolation of chick and mouse homologues of lin-41 that encode the RBCC-NHL family protein and their expression patterns. C. elegans lin-41 is one of the RBCC-NHL families and the predicted amino acid sequences of isolated two genes encode the same family proteins. Chick and mouse lin-41 expression was also observed in developing limb buds, branchial arches, and tail buds. The 3'UTRs of the mouse and chick lin-41 genes contain multiple let-7 complementary sites. Using luciferase assay, we showed that lin-41 expression can be regulated through let-7 complementary sites. |
