| First Author | Yoshitane H | Year | 2012 |
| Journal | EMBO Rep | Volume | 13 |
| Issue | 5 | Pages | 455-61 |
| PubMed ID | 22441692 | Mgi Jnum | J:186089 |
| Mgi Id | MGI:5431019 | Doi | 10.1038/embor.2012.37 |
| Citation | Yoshitane H, et al. (2012) JNK regulates the photic response of the mammalian circadian clock. EMBO Rep 13(5):455-61 |
| abstractText | The posttranslational regulation of mammalian clock proteins has been assigned a time-keeping function, but seems to have more essential roles. Here we show that c-Jun N-terminal kinase (JNK), identified by inhibitor screening of BMAL1 phosphorylation at Ser 520/Thr 527/Ser 592, confers dynamic regulation on the clock. Knockdown of JNK1 and JNK2 abrogates BMAL1 phosphorylation and lengthens circadian period in fibroblasts. Mice deficient for neuron-specific isoform JNK3 have altered behavioural rhythms, with longer free-running period and compromised phase shifts to light. The locomotor rhythms are insensitive to intensity variance of constant light, deviating from Aschoff's rule. Thus, JNK regulates a core characteristic of the circadian clock by controlling the oscillation speed and the phase in response to light. |
