| First Author | Wenger RH | Year | 1996 |
| Journal | Biochem Biophys Res Commun | Volume | 223 |
| Issue | 1 | Pages | 54-9 |
| PubMed ID | 8660378 | Mgi Jnum | J:33500 |
| Mgi Id | MGI:80979 | Doi | 10.1006/bbrc.1996.0845 |
| Citation | Wenger RH, et al. (1996) Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha. Biochem Biophys Res Commun 223(1):54-9 |
| abstractText | The heterodimeric hypoxia-inducible transcription factor HIF-1 is involved in the oxygen-regulated transcription of several genes including erythropoietin. Cloning and sequencing of the rr-subunit of mouse HIF-1 cDNA revealed a 90% overall homology to human HIF-1 alpha but lack of any similarity in the 5' untranslated region and translational start site. Mouse HIF-1 alpha is encoded by an Evolutionary conserved single-copy gene located on chromosome 12. We found a widespread constitutive expression of mouse HIf-1 alpha mRNA which was particularly high in lung and kidney. Despite a strong erythropoietin induction, HIF-1 alpha mRNA concentrations were not upregulated in hypoxic mouse tissues. (C) 1996 Academic Press, Inc. |
