| First Author | Castells MC | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 5 | Pages | 436-42 |
| PubMed ID | 11323698 | Mgi Jnum | J:296155 |
| Mgi Id | MGI:6467920 | Doi | 10.1038/87749 |
| Citation | Castells MC, et al. (2001) gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation. Nat Immunol 2(5):436-42 |
| abstractText | We have identified the integrin alpha(v)beta3 as a ligand for mouse gp49B1, thus identifying a new class of ligand for a member of the family of inhibitory immunoreceptors that bear C2-type immunoglobulin-like domains. The specific interaction was shown by both cell-protein and cell-cell binding assays. In addition, we found that the interaction of alpha(v)beta3 with gp49B1 on bone marrow-derived mouse mast cells inhibited antigen-induced immunoglobulin E-mediated cell activation. Because neither gp49B1 nor alpha(v)beta3 exhibit substantive allelic variation, their newly appreciated interaction may reflect an innate pathway for down-regulating the activity of mast cells. |
