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Publication : Reduced fertility with impairment of early-stage embryos observed in mice lacking Lgr4 in epithelial tissues.

First Author  Mohri Y Year  2010
Journal  Fertil Steril Volume  94
Issue  7 Pages  2878-81
PubMed ID  20638054 Mgi Jnum  J:307452
Mgi Id  MGI:6720934 Doi  10.1016/j.fertnstert.2010.05.050
Citation  Mohri Y, et al. (2010) Reduced fertility with impairment of early-stage embryos observed in mice lacking Lgr4 in epithelial tissues. Fertil Steril 94(7):2878-81
abstractText  Lgr4 is one of the genes identified as novel G protein-coupled receptor genes designated Lgr4-Lgr8, with high homology with FSH receptor, LH receptor, and TSH receptor genes, but studies of Lgr4-mutant mice have suggested that Lgr4 has essential functions in development. This is the first report describing the relationship between the functions of Lgr4 and female reproductive systems.
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