| First Author | Newrzella D | Year | 1992 |
| Journal | Biol Chem Hoppe Seyler | Volume | 373 |
| Issue | 12 | Pages | 1233-8 |
| PubMed ID | 1292508 | Mgi Jnum | J:28903 |
| Mgi Id | MGI:76442 | Doi | 10.1515/bchm3.1992.373.2.1233 |
| Citation | Newrzella D, et al. (1992) Molecular cloning of the acid sphingomyelinase of the mouse and the organization and complete nucleotide sequence of the gene. Biol Chem Hoppe Seyler 373(12):1233-8 |
| abstractText | The cDNA and complete gene encoding mouse acid sphingomyelinase (ASM) has been isolated using a homology screening approach. Comparison with the human sequence shows 81% sequence identity at cDNA level and 82% at the protein level. Homology is markedly reduced in the N-terminal region, especially in the presumed signal peptide. The six-exon gene structure is similar to the human one, except for the position of Alu1 elements. The alternatively used splice site 40 bp downstream of the human exon 2 is not conserved in the mouse gene and accordingly no such alternative splicing was found in mouse. |
